Turmeric Curcumin Bioavailability and Supplement Guide

Article by Stefan Burns - Updated June 2022. Join the Wild Free Organic email newsletter!

Turmeric is a flowering plant (Curcuma longa) of the ginger family and the bright orange rhizome it grows is used as a spice, most notably in India. Turmeric has many medicinal properties due to it’s unique blend of essential oils, plant polyphenols, and it’s main active ingredient curcumin which is a pigment chemical that gives turmeric its bright orange color.

Turmeric and its main active ingredient curcumin have become popular supplements worldwide because of their anti-inflammatory, anti-cancer, and antioxidant capabilities (1). There are many different ways turmeric and curcumin supplements are formulated, and some formulations are more effective than others because of their superior bioavailability.

This turmeric and curcumin buyers guide discusses the health benefits of turmeric, the science of how to increase it’s bioavailability, and the characteristics the best turmeric and curcumin supplements share.

Whole turmeric rhizome, slices, and powder

What Are Turmeric Supplements Good For?

The different active compounds of turmeric are known as curcuminoids, and for thousands of years Ayurvedic and Tradition Chinese Medicine have held turmeric root in high esteem due to its healing properties. Turmeric and its curcuminoids are helpful for a variety of health conditions such as cognitive ailments, pain, poor digestive function, and diseases that are inflammation based. I recommend incorporating turmeric spice into the diet for a generalized heath benefit and to also keep a curcumin supplement readily available so it can be used whenever pain or inflammation is experienced in excess. Curcuminoids are especially excellent at relieving pain, such as joint pain, a headache, or generalized discomfort. For those with ongoing health conditions which curcuminoids would help with, using a turmeric and curcumin supplement daily is a safe and practical option.

The drawback to turmeric is curcuminoids are not very bioavailable under normal circumstances. There have been many different attempts made to find a way to increase the bioavailability of curcumin, and this has flooded the supplement market with different turmeric and curcumin formulations some of which are well formulated and effective, and others which will have minimal health effect.

Without reading the research papers directly, detailed information regarding how to best take turmeric and curcumin supplements is hard to find, and this comprehensive guide to turmeric/curcumin supplements solves that problem by explaining the different type of turmeric supplements that exist on the market, their bioavailability and effectiveness, and the health benefits different formulations have on different systems of the body.

Curcuminoids

Curcumin is the yellow to orange pigment found in turmeric. The more alkaline the curcumin the darker the color. Curcumin has a massive catalogue of studied health benefits (2). It's anti-inflammatory, anti-depressive, a minor antioxidant, dramatically reduces symptoms of osteoarthritis, improves prostate health, reduces mucositis, and so much more. Curcumin is one of the most well researched supplements known, and more is still being discovered. It is mostly the curcuminoids in turmeric that give turmeric its noted health benefits.

Most pure curcumin supplements consist of a blend of different types of curcuminoids, such as curcumin, bisdemethoxycurcumin (BMC), and demethoxycurcumin (DMC), which all together usually total around 500 - 750 mg per serving. When analyzed, curcumin is the dominant curcuminoid at 60%, with BMC and DMC coming in around ~20% each.

The issue is that curcumin has nearly zero physiological effects on the body if taken by itself. Like turmeric powder, curcumin has terrible bioavailability, measured at less than 1%. Curcumin’s bioavailability is limited due to its poor solubility in the aqueous phase of the digestive tract. The body also rapidly metabolizes and excretes it. Bioavailability is also different between the sexes, with women on average reaching double the blood concentrations of curcumin compared to men. The reason for this difference in bioavailability between the sexes is unknown.

To fix the bioavailability problem, scientists have various methods to increase the bioavailability of curcuminoids in the body, and supplement manufacturers have created different formulations based on these scientific studies.

Turmeric and Curcumin Bioavailability

The reason so many different types of turmeric and curcumin supplements exist is because turmeric isn’t highly bioavailable in the human body under normal circumstances. If taking a supplement consisting of pure turmeric powder and nothing else, only 1-2% of the curcuminoids that make up part of the turmeric spice will enter into the bloodstream. Curcuminoids make up about 6% of turmeric by dry weight, so if taking a 1000 mg turmeric supplement, then ~1mg of curcuminoids will enter into the bloodstream, an insignificant effect.

Curcumin’s bioavailability is limited due to its poor solubility in the aqueous phase of the digestive tract. Furthermore, curcuminoids are rapidly absorbed by the tissues of the digestive system, limiting their ability to enter into the bloodstream. The digestive system, particularly the small intestine, is under constant stress from having to digest food and being in contact with the microbiome, and as a result it’s inflamed to some degree. Curcuminoids being potent antioxidants and anti-inflammatory compounds are quickly absorbed by the tissues of the gut for their own use.

Bioavailability is also different between the sexes, with women on average reaching double the blood concentrations of curcumin compared to men. The reason for this difference in bioavailability between the sexes is unknown.

If interested in using turmeric for its digestive healing effects, then taking plain turmeric without any bioavailability enhancement is desirable because it will specifically target the tissues of the gastrointestinal system and little else.

If curcuminoids are able to enter into the bloodstream in large quantities, then they exert their antioxidant and anti-inflammatory effects throughout the body, reducing pain and inflammation and enhancing cognition.

Methods of Increasing Curcumin Bioavailability

Curcumin is the main active ingredient found in turmeric responsible for its potent health and wellness benefits. Increasing its bioavailability increases its medicinal effect. That said, other compounds exist in raw turmeric that are health promoting, such as turmeric essential oils. Extracting more curcuminoids from turmeric increases the potency of its health effects, but for the complete benefits of turmeric, whole turmeric must also be consumed. The methods below describe how curcumin bioavailability can be increased, but keep in mind that the most effective curcumin supplement will also be one that incorporates some portion of powdered turmeric into its formulation.

Turmeric Dual Spectrum X:1 Extract

One way to achieve the synergistic health effects of raw turmeric while still receiving enough curcuminoids is to take a turmeric supplement concentrated through extraction.

Extraction is used to refine and purify a product. An extract is prepared using alcohol or water, and at the end of the concentration process the resulting extract is more potent. Depending on the level of extraction, curcuminoids can be much more heavily concentrated or just lightly more concentrated. With the right extract formulation, it is possible to create a turmeric supplement which retains all of the beneficial compounds of the turmeric rhizome while still increasing the potency and concentration of the main active curcumin compounds.

Curcumin with Piperine Supplements

Piperine is an enzyme inhibitor found in black pepper, giving black pepper its iconic pungency, and it has been shown to increase the bio-availability of curcumin (and by extension, turmeric) by 20x (3). Piperine works synergistically with curcumin, inhibiting curcumin's rabid absorption by the liver and intestinal wall. This inhibition allows curcumin to circulate into the blood stream for full body anti-inflammatory effects. Curcuminoids and piperine together enter into the blood stream rapidly peaking sharply about an hour after ingestion before being fully metabolized about 2-3 hours later.

When used in supplements, piperine is most often listed as biopiperine. Most studies which have researched the effect of piperine on curcumin absorption have used 20 mg of piperine per 2 grams of curcumin, and most curcumin/piperine supplements use 5 mg of piperine per 500 mg of curcuminoids, which is the same ratio.

Piperine is a bioavailability enhancer for more than just curcuminoids, and it has it’s own long list of health benefits (gastrointestinal aid, cognitive enhancer, antioxidant and anti-inflammatory) that overlap quite a bit with curcumin. Ancient Ayurveda knew this, and it’s why black pepper and turmeric spice are paired together for some many dishes in India.

Nootropics Depot sells a curcumin + piperine supplement which contains 1000 mg of 95% standardized curcuminoids and 6 mg of piperine.

Micellar Curcumin Supplements

Micellar curcumin is a special type of curcumin supplement shown to have better bioavailability that curcumin paired with piperine. Curcumin is a lipophilic molecule, meaning it is poorly water soluble, and that in large part is why curcumin is so poorly bioavailable. A micelle as shown to the left is a collection of lipid (fat) molecules that can simultaneously interact with water and lipids.

When curcuminoids are encapsulated in micelles, their ability to enter into the bloodstream skyrockets, and they stay active in the body for much longer

Through a special chemical process, curcumin molecules can be contained inside micelles. Protected by the micelles which are able to interact with water soluble materials and membranes, the curcumin is much more easily transported though the digestive system and into the blood stream.

Micellar curcumin is incredibly bioavailable (4), more so than curcumin taken with piperine, and curcumin concentrations in the blood stream stay elevated for up to a day as compared to a few hours with curcumin and piperine supplements. This approach to increase curcumin bioavailable is completely independent of enzyme inhibition which is how piperine works.

Because the addition of micelles increases the bioavailability of curcumin so dramatically, its health effects can be too potent at times, and caution is recommended. In a study measuring micellar curcumin’s bioavailability (4), the researchers took note of the side effects observed. Out of 13 women and 10 men total, 7 women and 3 men experienced mild nausea. Since curcumin is ~2x more bioavailable in women in men, we’d speculate that more women experienced nausea than men because they received too much curcumin. 1 woman even vomited! The nausea prevalent with use of micellar curcumin did not occur when those same men and women used the other two formulations (Micronized Curcumin and Meriva® type formulation). Unless you have a serious health condition that would benefit from all day elevated curcumin blood levels, I would stick to the safer and more widely available curcumin with piperine supplements.

Nootropics Depot sells a Longvida curcumin supplement which uses micellular technology to dramatically increase the bioavailability of curcuminoids.

Micronized Curcumin Supplements

Micronized curcumin is effectively “crystallized” curcumin. The method one study used to create micronized curcumin involved mixing 25% curcumin powder with 58.3% triacetin (an anti-fungal) and 16.7% panodan (an emulsifier) and spraying and soaking the solution onto porous silicon dioxide crystals (basically glass, inactive physiologically) (5). The resulting micronized curcumin powder contained ~15% curcumin.

Micronized curcumin was found to be 9x more bioavailable than regular standardized curcumin averaged between men and women. Micronized curcumin was also shown to be more bioavailable in women compared to men. Compared to regular curcumin, the micronized version was more bioavailable, but still less so than curcumin with piperine.

Micronizing curcumin is a complex process which uses a lot of chemicals, and I would stay away from micronized curcumin supplements for these reasons.

Curcumin with Turmeric Essential Oils Supplements

As discussed, it is turmeric/curcumin’s poor water solubility that negatively affects its bioavailability. When taken with fats, curcumin’s bioavailability improves.

It is also usually the case that when an herb or root with medicinal properties is taken in its original whole form a type of entourage effect occurs. With the entourage effect, the secondary compounds which are normally standardized out can now contribute to and boost the overall health effect, and the benefits of supplements that take this into account this holistic nature are broader in their beneficial medicinal effect.

The essential oils found within the turmeric root are some of those secondary compounds, and it’s been shown that when standardized curcumin is taken with turmeric essential oils the bioavailability of curcumin improves significantly (6). This increase in bioavailability is because of the synergistic effect these plant compounds exhibit, and also the fact that the essential oils add fat to the supplement, aiding assimilation into the blood stream.

One formulation that employs this tactic is known as BCM-95 (Biocurcumax), and it’s been shown to be 7x more bioavailable than standard curcumin (7). BCM-95 is more bioavailable than curcumin with piperine, and with piperine added to a BCM-95 curcumin formulation, I think the bioavailability would be improved even further, possibly rivaling or surpassing the bioavailability of micellar curcumin due to the entourage effect.

Curcumin with Emulsifiers (lecithins)

Emulsifiers such as lecithins have also been used in an effort to increase the bioavailability of curcumin. The idea is that the emulsifiers help to carry the curcumin through the gut and into the bloodstream. Meriva is one such formulation, and overall bioavailability is improved compared to just curcumin, but not by much. In one study, a reference dose of 1800 mg of standardized curcuminoids, was compared to a Meriva formulation (8). Compared to the reference dose, the Meriva formulation was 5.5x more potent and stayed in the bloodstream for longer. Interestingly, the Meriva formulation dramatically boosted the bioavailability of demethoxycurcumin (DMC), a less prominent curcuminoid.

The specific physiological effects of just DMC are not well studied yet, and it is unknown why the addition of lecithins to standardized curcuminoids dramatically increases the bioavailability of DMC compared to the other curcuminoids.

Fermented Turmeric Supplements

Fermented turmeric is yet another supplement type. During fermentation curcumin is metabolized by bacteria into a different yet similar compound called tetrahydrocurcumin (THCC). Typically chemical reactions result in more stable compounds, and it’s been observed that THCC is more stable than curcumin. Likely as a result of it’s increased stability, THCC has a longer half-life of 323 minutes in plasma versus 111 minutes for curcumin.

One study which measured the effect of fermented turmeric observed that 36 hours of fermentation using Aspergillus oryzae at 25°C reduced regular curcumin levels from 2.0 mg/g to 0.79 mg/g (9). The reduction in curcumin in fermented turmeric is offset by the creation of THCC, though the exact ratios of how fermentation converts curcumin to tetrahydrocurcumin is unknown.

With rats, tetrahydrocurcumin appears to be more bioavailable than curcumin (10). In general its been observed that rats absorb curcumin much easier than humans. Like curcumin, THCC was found to primarily be absorbed by the intestine and liver. No studies have been performed measuring tetrahydrocurcumin’s bioavailability in humans or rats when paired with piperine or encapsulated in micelles.

Fermented turmeric is highly experimental and as of now it’s medicinal effects are poorly quantified. Fermented turmeric doesn’t appear to be unsafe in any way considering normal usage, but the effects on your body are not well researched. Below are two non-comprehensive lists laid out in layman’s terms outlining some of the benefits of curcumin over THCC, and vice versa. Nootropics Depot sells a Curowhite curcumin supplement which is standardized to 25% to contain dura, hexa, and octa curcuminoids.

Curcumin Benefits over Tetrahydrocurcumin:

• Curcumin was more effective than THCC in preventing skin tumors in mice

• Curcumin was more effective than THCC as an antioxidant

• Curcumin induced apoptosis (cellular death) of leukemia cells but THCC did not

• Curcumin, but not THCC, was effective in reducing amyloid plaque burden and amyloid aggregation (think Alzheimers)

• Curcumin, but not THCC, inhibited Ca(2+) influx through CRAC for activating immune cells

• Curcumin, but not THCC, inhibited entry of hepatitis C virus genotypes into human liver cells

• Curcumin inhibited type A influenza virus infection to a greater extent than THCC by interfering with viral hemagglutination activity (red blood cell clumping)

Tertahydrocurcumin Benefits over Curcumin:

• THCC was more active than curcumin as an antioxidant

• THCC was more active than curcumin for suppression of LDL oxidation

• THCC was equal to curcumin in potency for suppression of histamine release

• THCC was more active than curcumin in normalizing blood glucose and improvement of altered carbohydrate metabolic enzymes in diabetic animals

• THCC was more active than curcumin in increasing plasma insulin in diabetic rats

• THCC was more active than curcumin for antidiabetic and antihyperlipidemic (blood lipid lowering) effects

• THCC was more active than curcumin in a hepatoprotective role in CCL4-induced liver damage in rats and alcoholic liver disease model rats

• THCC was more active than curcumin as an antihypertensive

Comparing Curcumin Supplement Effectiveness

Below are the different well studied curcumin supplements compared across three markers, Cmax, AUC, and Tmax.

• Cmax is the peak concentration reached in blood plasma, expressed in nmol/L.

• AUC (area under the curve) is the concentration in blood plasma over time, expressed as nmol/L * H

• Tmax is the time it took to reach Cmax. Higher values for Cmax and AUC are typically better.

A lower value for Tmax is preferred if you are looking for a fast acting curcumin supplement for immediate pain relief. A higher Tmax value indicates a broader effect.

Cmax (nmol/L)

• 7.1 - 2g Curcumin

• 41.6 - 410mg Micronized Curcumin

• 489 - 2g Curcumin, 20mg Piperine

• 1240 - 2g BCM-95®

• 1765 - 297mg Meriva

• 3228 - 410mg Micellar Curcumin

AUC (nmol/L * H)

• 65.6 - 2g Curcumin (measured for 24 hours)

• 217.2 - 2g Curcumin, 20mg Piperine (measured to zero after 3 hours)

• 582.7 - 410mg Micronized Curcumin (measured for 24 hours)

• 1460.4 - 297mg Meriva (measured for 24 hours)

• 8690 - 2g BCM-95® (measured for 8 hours)

• 12147.7 - 410mg Micellar Curcumin (measured for 24 hours)

Tmax (H - hours)

• 0.69 - 2g Curcumin, 20mg Piperine

• 1.1 - 410mg Micellar Curcumin

• 3.0 - 2g BCM-95

• 3.8 - 297mg Meriva

• 7.5 - 2g Curcumin

• 7.5 - 410mg Micronized Curcumin

If choosing a turmeric/curcumin supplement based purely off of the blood markers above, micellar curcumin is the clear winner, with the BCM-95 formulation coming in second and the Meriva formulation coming in third.

There are other important considerations besides just Cmax and AUC values though. Anytime a drug, supplement, or food is ingested, body chemistry is altered. Care must be taken when taking supplements, as too much of even a good thing can have negative health effects. Take for example that curcumin strongly activates AMPK (adenosine monophosphate-activated protein kinase), an very important enzyme which governs metabolism (aka fat oxidation or fat storage).

With micellar curcumin, curcumin concentrations in the blood are elevated very strongly and for a long time, overly activating AMPK and other systems throughout the body. If using a curcumin supplement everyday as many people do, using a micellar curcumin supplement will strongly influence AMPK 24/7, and over a long duration the effect this will have hasn’t been studied yet. Positive or negative, the effects are currently unknown. The high reports of nausea from the use of micellar curcumin is also troubling. With a supplement to be used often, exerting caution is always the best approach. Start conservatively, gauge how it affects your body, both physiologically and psychologically, and tweak the dosing from there.

Micellar curcumin was the front runner based on having the highest Cmax and AUC values, but with these concerns noted, I recommend a more conservative approach, and a curcumin formulation that is more holistic in nature.

Where to Buy Curcumin Supplements

After studying into the health benefits of curcumin and how its bioavailability can be increased, the best marketplace I have found for curcumin supplements is Nootropics Depot. They carry three different types of curcumin supplement, each having their unique bioavailability differences which are worth trying separately.

Curcumin + Piperine Capsules

The standard curcumin supplement they sell is a blend of 1000 mg of 95% standardized curcuminoids and 6 mg piperine derived from black pepper. This is a good curcumin supplement that is readily bioavailable and can be used for a wide range of purposes, from treating headaches to joint pain or to boost metabolism.

Longvida Curcumin Supplement

Nootropics Depot also carries a Longvida curcumin supplement. Longvida curcumin has been coated in a blend of highly purified fatty acids and phospholipids, which increases greatly increases curcuminoid bioavailability into the bloodstream. Each capsule contains 400 mg of the Longvida opimized curcumin extract.

Curowhite Curcumin Supplement

Lastly Nootropics Depot carries a Curowhite curcumin supplement which is a blend of tetra, hexa, and octa-curcuminoids standardized to at least 25%. These hydrogenated curcuminoids have differing effects physiologically than regular curcuminoids and are worth experimenting with.

1-2 servings of the any of the curcumin supplements sold by Nootopics Depot will be enough to use for digestive relief, pain relief, headaches, inflammatory diseases, and for general health and wellness purposes.

Mountain Rose Herbs also sells a variety of turmeric products, from the rhizome itself to different supplements and teas.

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References:

1. Hewlings SJ, Kalman DS. Curcumin: A Review of Its' Effects on Human Health. Foods. 2017;6(10)

2. Kamal Patel. Curcumin. Examine

3. Shoba G, Joy D, Joseph T, Majeed M, Rajendran R, Srinivas PS. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Med. 1998;64(4):353-6.

4. Schiborr C, Kocher A, Behnam D, Jandasek J, Toelstede S, Frank J. The oral bioavailability of curcumin from micronized powder and liquid micelles is significantly increased in healthy humans and differs between sexes. Mol Nutr Food Res. 2014;58(3):516-27.

5. Schiborr C, Kocher A, Behnam D, Jandasek J, Toelstede S, Frank J. The oral bioavailability of curcumin from micronized powder and liquid micelles is significantly increased in healthy humans and differs between sexes. Mol Nutr Food Res. 2014;58(3):516-27.

6. US Patent 7883728B2

7. Antony B, Merina B, Iyer VS, Judy N, Lennertz K, Joyal S. A Pilot Cross-Over Study to Evaluate Human Oral Bioavailability of BCM-95CG (Biocurcumax), A Novel Bioenhanced Preparation of Curcumin. Indian J Pharm Sci. 2008;70(4):445-9.

8. Cuomo J, Appendino G, Dern AS, et al. Comparative absorption of a standardized curcuminoid mixture and its lecithin formulation. J Nat Prod. 2011;74(4):664-9.

9. Kim SW, Ha KC, Choi EK, et al. The effectiveness of fermented turmeric powder in subjects with elevated alanine transaminase levels: a randomised controlled study. BMC Complement Altern Med. 2013;13:58.

10. Pianpumepong Plangpin, Et al. Study on enhanced absorption of phenolic compounds of Lactobacillus‐fermented turmeric (Curcuma longa Linn.) beverages in rats. International Journal of Food Science & Technology 47(11). November 2012.

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